Potential side effects of IVF treatment

Side effects of clomiphene citrate and gonadotrophins are rare and of short duration. Although concerns have been expressed over prolonged use of clomiphene, short-term, closely monitored treatment is considered safe. However, there are two important risks from ovulation induction - ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy. When the likelihood of either is detected via ultrasound doctors typically stop the treatment cycle and do not proceed to the hCG injection.

The two potential side effects are:

• Ovarian hyperstimulation syndrome (OHSS): A rare condition which occurs when too many follicles grow and cause abdominal distension, discomfort, nausea and sometimes difficulty breathing. In extreme cases hospitalization is necessary. OHSS is potentially serious but can be avoided by careful monitoring.


• Multiple pregnancy: Studies show that multiple pregnancies are associated with an increased risk of miscarriage and premature delivery.